COMPARATIVE EVALUATION OF NEW OSTEOPLASTIC RAW MATERIALS BASED ON THE RESULTS OF ACUTE VENOM RESEARCH

2021-03-26
Journal: Stomatologiya
Issue: No. 2(83) (2021)
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Akbarov, A., Ziyadullaeva, N., Raxmanov, A., & Axmedov, M. (2021). COMPARATIVE EVALUATION OF NEW OSTEOPLASTIC RAW MATERIALS BASED ON THE RESULTS OF ACUTE VENOM RESEARCH. Stomatologiya, (2(83), 8–10. Retrieved from https://uzda.uz/index.php/stomatologiya/article/view/187

Keywords:

osteoplastic material / median lethal dose / acute toxicity

Abstract

Comparative assessment of the degree of harmful effects on experimental animals of the new osteoplastic material 47.5B and domestic bioactive glass BG-1D and assessment of its safety for use as an osteoplastic material. Material and methods: Three series of experiments were earned out and lethal doses were determined for the intraperitoneal and intragastric routes of administration of the drug to laboratory animals. Results: LD50 47.5B was 4274.51:4770.58 mg/kg when administered intragastrically and 2358.31:2895.65 mg/kg when administered intraperitoneally to rats. In animals that received bioactive glass BG-1D, this indicator changed slightly, amounting to 3439.04:3810.53 and 1732.77:2730.93 mg/kg, respectively. Conclusions: These materials can be attributed to practically non-toxic substances (according to the results of intraperitoneal administration of a suspension of substances to rats and mice) and to low-toxic substances (according to the results of intragastric M administration of a suspension of substances to rats).